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Objective: Through searching the information of health food with the function of alleviating visual fatigue published on the Special Food Information Query Platform, and the product information data of ophthalmic proprietary Chinese medicine with health care function in the prescription database of Chinese patent medicine based on Pharmaceutical Intelligence data network, so as to provide the basis and reference for the development of the health food formulations and products with the function of relieving visual fatigue. Methods: Microsoft Excel 2016 software and Traditional Chinese Medicine Inheritance System were used to make statistics on the detected product information and analyze its formula characteristics. Results: A total of 141 kinds of health food with visual fatigue relief function were collected, of which 64 kinds (45.4%) contained traditional Chinese medicine in the formula of health food. There were six herbs of Chinese materia medica raw materials with frequency ≥ 5, which were used 145 times (72%), from high to low, Chrysanthemum morifolium, Lycium barbarum, Cassiae Semen, Mori Fructus, Rehmannia glutinosa and Poria cocos were used respectively. Three new prescriptions were obtained by unsupported entropy clustering. Non-traditional Chinese medicine raw materials are widely used in health food to alleviate visual fatigue, there were 60 products containing foreign natural plant resources and 17 products containing xanthin and vitamins. According to statistics on the products with health function in ophthalmic Chinese patent medicine, there were seven kinds of traditional Chinese medicine materials with frequency ≥ 4, which were used 32 times (29%), from high to low, they were Lycium barbarum, Cassiae Semen, Cuscuta chinensis, Rehmannia glutinosa, Chrysanthemum morifolium, Schisandra chinensis, and Plantago asiatica. A new prescription was obtained by unsupervised entropy hierarchical clustering. Conclusion: The choice of raw materials of Chinese materia medica in health food is basically consistent with traditional Chinese medicine theory in the treatment of visual fatigue principle, that is, nourishing the liver and kidney, calming liver and improving eyesight. However, they are different in the selection range of traditional Chinese medicine raw materials, the compatibility of raw materials, the types of dosage forms and so on. In addition, under the guidance of syndrome differentiation and health care theory, this paper attempts to apply the statistical method of literature data processing to screen new formulas and develop new products, which opens up new ideas and methods for the research and development of health care products of traditional Chinese medicine compound.
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To explore the regularity of traditional Chinese medicine(TCM) prescriptions for cardio-cerebrovascular diseases,the core drug groups with common therapeutic effects on cerebrovascular diseases represented by stroke and cardiovascular diseases represented by coronary artery disease were extracted,and their consistency and difference in the treatment of different diseases were analyzed.A total of 388 Chinese patent medicines were collected for the treatment of cerebrovascular diseases,cardiovascular diseases and cardio-cerebrovascular diseases.The dominant and recessive patterns of Chinese patent medicines in clinical use were found by "frequency analysis","compatibility analysis" and "network analysis" respectively.According to the findings of the three parts,Salviae Miltiorrhizae Radix et Rhizoma,Chuanxiong Rhizoma,Carthami Flos and Astragali Radix have a high frequency of use in the treatment of brain disease,heart disease and both,with frequent combined medication.Data mining confirmed the core drug combinations for the treatment of cerebral and cardiac vascular diseases,so as to reveal the similarities and differences in the drug use of Chinese medicine for these diseases,and provide a basis for the rational use of traditional Chinese medicine in clinical practice.This analysis also defines a new direction for the future development of prescription combinations for different indications of cerebral and cardiac diseases.
Subject(s)
Humans , Cardiovascular Diseases , Drug Therapy , Cerebrovascular Disorders , Drug Therapy , Data Mining , Drugs, Chinese Herbal , Therapeutic Uses , Medicine, Chinese Traditional , PrescriptionsABSTRACT
Objective To analyze the composing principles of the traditional Chinese medicine (TCM) prescriptions for eczema by data mining methods.Methods The CNKI,VIP,Wanfang and SinoMed from inception to the December 31st 2016 were searched,which were collected into the traditional Chinese medicine inheritance support system (TCMISS) and analyzed by data mining methods,which included frequency analysis,Cluster Analysis and correlation rules.Results Based on the analysis of 51 cases of TCM prescriptions reported in literatures,16 herbs (frequency≥8) were found frequently used.And the results showed that 22 combination herbs (supporting coefficient=8),4 association rules (supporting coefficient=8 and confidence coefficient=0.8),7 core combinations and 1 new TCM prescription were found.Conclusions The TCM prescriptions for eczema are mainly composed of herbs with heat-clearing effect,especially with damp-drying effect,supplemented by herbs with blood-nourishing,blood-cooling and rheumatism effects.
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Objective To analyze the treatment and medication rules of formulae containing prepared rehmannia root in Pharmaceutical Standard of Ministry of Public Health of the People's Republic of China-Traditional Chinese Patent Medicine (referred to as Traditional Chinese Patent Medicine). Methods Through Traditional Chinese Medicine Inheritance Support Platform (V2.5), prescriptions containing prepared rehmannia root in traditional Chinese patent medicine were selected and collected to build the database. Frequency counts,association rules and other data mining methods were used to analyze the frequency of indication syndromes and medicine combination of prescription containing prepared rehmannia root, and the compatibility rule of high frequency drug pairs and the rescription rule of core syndromes were analyzed. Results There were a total of 467 prescriptions containing pepared rehmannia root, involving 28 combinations of commonly used Chinese herbals (support degree 30%). The compatibility source of high-frequency drug pairs of prepared rehmannia root and Angelicae Sinensis, prepared rehmannia root and Astragalus embranaceus were both of Shiquan-Dabu decoction in Taiping Huimin Heji Ju Fang (support degree 40%). There were a total of 81 indication syndromes, and among them, there were 16 kinds of high-frequency indication syndromes (the frequency greater than or equal to 10). The core drug combination of high-frequency indication syndromes of "deficiency of both qi and blood" (137 times) and "deficiency of kidney yang" (63 times) were the subtract of Shiquan-Dabu decoction and Yougui pill in Jingyue Quanshu respectively. Conclusions Prepared rehmannia root is mainly compatible with herbs of nourishing blood, supplementing qi and invigorating yang in the traditional Chinese patent medicine containing prepared rehmannia root. The traditional Chinese patent medicine containing prepared rehmannia root were based mainly on classical prescriptions. This study can provide reference for clinical application and new drug development of pepared rehmannia root.
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Through searching the information of chemical liver injury protection function of health food on the State Food and Drug Administration website and using Microsoft Excel 2016 software and Traditional Chinese Medicine Inheritance System, to analyze formula characteristics of health food and provide the basis for the formulation of health food with auxiliary protective function in chemical liver injury and the development of the product. A total of 325 kinds of health food were collected, of which 282 (86.8%) health food formulations contained Chinese materia medica (CMM) raw materials. The number of health food with one single health care function and two healthy functions was 192 and 133, respectively. In terms of dosage forms, there were 156 capsules, which account for about half of the total. Moreover, there were 21 kinds of CMM raw materials with more than 18 of the use frequency (f) and accumulated 768 times (73%). Nine new prescriptions were obtained by unsupervised entropy hierarchical clustering. The CMM is widely used in the health food which has the auxiliary protective function in the chemical liver injury. The choice of dosage forms is based on convenience of taking and carrying. Five commonly used functional ingredients are total flavonoids, crude polysaccharides, puerarin, total saponins, and taurine. The choice of CMM is basically consistent of the principle of traditional Chinese medicine treatment of chemical liver disease which are detoxification, strengthening the body resistance, promoting blood circulation, clearing away heat, dehumidification and so on. The most commonly used drugs are anti-alcoholismic drugs, tonic medicine, blood-activating and stasis-resolving drugs, heat-clearing drugs, and damp-draining diuretic. Nine new prescriptions found by software must be further evaluated in combination with the theory and practice of Chinese medicine and comprehensive analysis.